1、 Used as a slow-release material
1. Methoxynapropionic acid controlled-release tablets
Quick release granule formula: 300mg methoxynaphthalene propionic acid, 880mg lactose, 18mg PVP, 30mg starch, 18mg carboxymethyl starch sodium, 1.2mg magnesium stearate;
Controlled release granule formula: 450mg methoxynaphthalene propionic acid, 171mg hydrogenated castor oil, 54mg ethyl cellulose;
Mix the above two types of particles evenly and press them into tablets.
2. Long acting potassium chloride tablets
Take a prescription amount of potassium chloride crystals and suspend them in molten cetamol, hydrogenated castor oil, and stearic acid. Stir until almost solidified, then pass through a 20 mesh sieve to form particles. The particles are then mixed with gelatin solution and passed through a 10 mesh sieve for granulation. After drying at room temperature, add lubricant and press into a core, then coat it with sugar.
3. N-one (a hydroxyethyl) nicotinoyl nitrate skeleton tablets
Take 90g of hydrogenated castor oil and disperse it into particles with a diameter of 1.5 µ m using micro powder grinding. Immediately mix it with 8g of hydroxypropyl cellulose. The mixture is granulated by mixing 20g of 10% hydroxypropyl cellulose with 43g of water and dried at 50 ℃ to obtain particle A. Take 2.5g of the above mixture and add 7.5g of the main drug to obtain particle B. Take 5.9g of lactose, 3g of microcrystalline cellulose, 0.1g of magnesium stearate, and 1g of the main drug and mix them to obtain particle C. Mix particles A, B, and C and press them together to obtain particle C.
4. Slow release coating material
Specific drugs require a coating layer to achieve sustained release effect, and hydrogenated castor oil is one of the commonly used sustained release materials, with a general dosage of 5.0% -20.0% of the total weight of the coating layer.
2、 Used as a lubricant
Hydrogenated castor oil can be used as a lubricant for tablets. Although its lubricating effect is not as good as magnesium stearate, hydrogenated castor oil is a very good choice for a small number of tablets that produce sticking during the compression process. For example, hydrogenated castor oil is needed as a lubricant for clopidogrel hydrogen sulfate tablets.
In fact, most drugs with strong J properties (hydrophilic drugs) and drugs that are prone to causing flower spots during the tablet pressing process can use hydrogenated castor oil as a lubricant, which can not only provide lubrication, but also prevent sticking and flushing, and have a hydrophobic effect, making it less prone to flower spots.
Hydrogenated castor oil is generally used as a lubricant by external addition, with a dosage of 0.2% -2%
3、 Used as a base for ointments or suppositories
Various plant oils such as castor oil, sesame oil, peanut oil, and tea seed oil are commonly used as solvents or oil phase matrices in pharmaceutical formulations. However, due to the susceptibility of plant oils to oxidation and rancidity, which affects the long-term stability of pharmaceutical formulations, research has found that after hydrogenation, plant oils are less prone to oxidation and rancidity, and their oil properties do not undergo significant changes.
Therefore, for ointments and suppositories that require vegetable oil or liquid paraffin, hydrogenated castor oil can be used. As hydrogenated castor oil is a waxy solid with a high viscosity after melting, it can significantly reduce the amount of oil or oil phase used, and the paste is smoother and more delicate.
